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Publications of the team members:

Main Publications:


1. Aberdam E, Roux LN, Secrétan PH, Boralevi F, Schlatter J, Morice-Picard F, Russo C, Bodemer C, Missero C, Cisternino S, Aberdam D* and Hadj-Rabia S*. Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1MET/APR-246. Cell Death Dis. 11(1):30. * co last senior authors 

2. Petit I, Levy A, Aberdam D. Purification of Extracellular Microvesicles Secreted by Dermal Fibroblasts. Methods Mol Biol. 2020;2154:63-72. 


1. le Riche A, Aberdam E, Marchand L, Frank E, Jahoda C, Petit I, Bordes S, Closs B and Aberdam D. Extracellular vesicles from activated dermal fibroblasts stimulate hair follicle growth through dermal papilla-secreted norrin. Stem cells, 37(9):1166-1175.  Press release

2. Soares E, Xu Q, Li Q, Qu J, Zheng Y, Raeven HHM, Brandao K, Petit I, van den Akker WMR, Aberdam D, Tang F and Zhou H. Single-cell RNA-seq identifies a reversible epithelial-mesenchymal transition in abnormally specified epithelia of p63 EEC syndrome. Proc Natl Acad Sci U S A, 116(35):17361-17370.

3. Bhattacharya S, Serror L, Nir E, Dhiraj D, Altshuler A, Khreish M, Tiosano B, Hasson P, Panman L, Luxenburg C, Aberdam D, Shalom-Feuerstein R. SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium. Stem Cells. 2019 Mar;37(3):417-429. 


1. Roux LN, Petit I, Domart R, Concordet JP, Qu J, Zhou H, Joliot A, Ferrigno O and Aberdam D. Modeling of aniridia-related keratopathy by CRISPR/Cas9 genome editing of human limbal epithelial cells and rescue by recombinant PAX6 protein. Stem cells, 36(9):1421-1429. 

Talk by Lauriane: link to FSSCR


1. Nagosa S, Friederike Leesch F.,...., Aberdam D*  and Shalom-Feuerstein R*. MicroRNA-184 induces a commitment switch to epidermal differentiation. Stem cell Report 9(6):1991-2004. * co last senior authors

2. Aberdam E., Petit I., Sangari L and Aberdam D. Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing. Plos One 12(6):e0179913. 


1. Erbani J, Aberdam D*, Larghero J and Vanneaux V. (2016). Pluripotent stem cells and other innovative strategies for the treatment of ocular surface diseases. Stem Cell Reviews and Reports, 12:171-8. *co-corresponding author.


1. Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Nahmias Y* and Aberdam D*. Glycolysis-mediated Changes in Acetyl-coA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells. Cell Metab. 21(3):392-402. * co last senior authors. 

Preview by Dr. G. Daley: Shyh-Chang N, Daley GQ. Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metab. (2015) 21(3):349-50.

2. Moussaieff A, Kogan NM, Aberdam D. Energy Metabolites: Key Mediators of the Epigenetic State of Pluripotency. Stem Cells. 33(8):2374-80.

3. Antonini D, Sirico A, Aberdam E, Ambrosio R, Campanile C, Fagoonee F, Aberdam D, Brissette JL and Missero C. 2015. A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.  Nucl Ac Res. 43(2):862-74.

4. Warshauer E, Samuelov L, Sarig O, Vodo D, Bindereif A, Kanaan M, Gat U, Fuchs-Telem D, Shomron N, Farberov L, Pasmanik-Chor M, Nardini G, Winkler E, Meilik B, Petit I, Aberdam D, Paus R, Sprecher Eli and Nousbeck J. (2015) RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63. Exp. Dermatol., 24(8):618-22.

5. Levy A, Petit I and Aberdam D. (2015) Pluripotent stem cells as a cellular model for skin: relevance for physiopathology, cell/gene therapy and drug screening. Eur. J. Dermatol, Apr;25 Suppl 1:12-7.

6. Aberdam D. [Metabolic switch in pluripotent stem cells: identification of a novel pathway]. Med Sci (Paris). 2015 Jun-Jul;31(6-7):581-3.  


1. Sabapathy K, Nagakawara A, Aberdam D. The 6th International p63/p73 Workshop: the C(ancer) and D(evelopmental) roles of p63 and p73. Cell Death Differ. 2014 21, 1340-2.

2. Tattikota SG, Rathjen T, McAnulty SJ, Wessels HH, Akerman I, van de Bunt M, Hausser J, Esguerra JL, Musahl A, Pandey AK, You X, Chen W, Herrera PL, Johnson PR, O'Carroll D, Eliasson L, Zavolan M, Gloyn AL, Ferrer J, Shalom-Feuerstein R,  Aberdam D, Poy MN. Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell. Cell Metab. 19(1):122-34.

3. Wolchinsky Z, Shivtiel S, Kouwenhoven EN, Putin D, Sprecher E, Zhou H, Rouleau M, Aberdam D. Angiomodulin is required for cardiogenesis of embryonic stem cells  and is maintained by a feedback loop network of p63 and Activin-A. Stem Cell Res. 2014 Jan;12(1):49-59.

4. T. Goldsmith, O. Eytan, L. Magal, M. Solomon, S. Israeli, E. Warshauer, M. Grafi-Cohen, D. Aberdam, H. van Bokhoven, J.H. Zhou, O. Sarig, E. Sprecher,  J. Nousbeck. A novel mutation inTP63 causing a mild ectodermal dysplasia phenotype. J. Invest. dermatol. 134, 2277-80.

5. Freije A., Ceballos L., Cagigas M., Molinuevo R., Alonso P., Rodriguez R., Menendez P., Aberdam D., De Diego E. and Gandarillas A. Inactivation of p53 in human keratinocytes leads to squamous differentiation and shedding via replication stress and mitotic slippage. Cell Report. 9(4):1349-1360.

6. Leshansky L, Aberdam D, Itskovitz-Eldor J, Berrih-Aknin S. Human Embryonic Stem Cells Prevent T-Cell Activation by Suppressing Dendritic Cells Function via  TGF-Beta Signaling Pathway. Stem Cells. 2014 Dec;32(12):3137-49.


-1.  Shalom-Feuerstein R, Serror L, Aberdam E, Müller FJ, van Bokhoven H, Wiman KG, Zhou H, Petit I* and Aberdam D*. (2013) Impaired epithelial differentiation of induced pluripotent stem cells from EEC patients is rescued by APR-246/PRIMA-1MET. Proc Natl Acad Sci U S A,  110(6):2152-2156. * co last authors

-2. Robicsek, O, Karry R., Petit I, Salman Kesner N., Müller FJ., Klein E., Aberdam D. and D. Ben Shachar. (2013) Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients. Molecular Psychiatry, 18, 1067-76.

-3. Zhou H, Aberdam D. A step closer toward therapies for p63-related disorders. Rare Dis.2013 Mar 12;1:e24247.


-1. Petit I, Salman Kesner N, Karry R, Robicsek O,  Aberdam E, Müller FJ, Aberdam D* and Ben Shachar D*. Induced Pluripotent Stem Cells from hair follicles as a novel cellular model for neurodevelopmental disorders. Stem cell Res. Jan;8(1):134-40. (*co-last authors) pdf

-2. Shalom-Feuerstein R, Serror L, De La Forest Divonne S, Petit I, Aberdam E, Odile Damour O, Vigouroux C, Solomon A, Camargo L, Gagioli C, Itskovitz-Eldor J, Ahmad S and Aberdam D (2012) Pluripotent stem cell model reveals essential roles for miR-450b-5p and miR-184 in embryonic corneal lineage specification. Stem cells 30(5):898-909. pdf

-3. Fuchs G, Shema E, Vesterman R, Kotler E,  Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, Yu X, Hanna J, Aberdam D, Domany E and Oren M. (2012) RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol. Cell, 46(5):662-73.

-4. Hof-Nahor I, Leshansky L, Shivtiel S, Eldor L, Aberdam D, Itskovitz-Eldor J, Berrih-Aknin S. Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes. J Cell Sci. 2012 Jul 5. [Epub ahead of print]

-5. Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D,  Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J Cell Biol.199(2): 347-63. pdf


-1. Rouleau M, Medawar A, Hamon L, Shivtiel S, Wolchinsky Z, Zhou H, De Rosa L, Candi E, Divonne de la Forest S, Mikkola ML, van Bokhoven H, Missero C, Melino G, Puceat M and Aberdam D. TAp63 is important for cardiac differentiation of embryonic stem cells and heart development. Stem cells 29(11):1672-83.  pdf. 

-2. Shalom-Feuerstein R., Lena AM., Zhou H., De La Forest Divonne S., Van Bokhoven H., Candi E., Melino G. and  Aberdam D. DNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Diff.18:887-96. pdf

-3. V Marcel, I Petit, F Murray-Zmijewski, T Goullet de Rugy, K Fernandes, V Meuray, A Diot, DP. Lane, D Aberdam and JC Bourdon. Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity, Cell Death Diff.19:816-26. pdf

-4. Paris M, Rouleau M, Pucéat M and Aberdam D. Regulation of skin aging and heart development by TAp63. Cell Death Diff. 19(2):186-93. pdf


-1. Aberdam E, Barak E, Rouleau M, De Laforest S, Berrih-Aknin S, Suter DM, Krause KH, Amit M, Itskovitz-Eldor J, and Aberdam D. A pure ectodermal cell population derived from human embryonic stem cells. Stem cells 26:440-444. pdf 

-2. Medawar A, , Rostagno P., De Laforest Divonne S, Gambaro K., Rouleau M. and Aberdam D. DNp63 is essential for epidermal commitment of embryonic stem cells. Plos One, 3:e3441. pdf

-3. Aberdam D., Candi E., Knight R.A. and Melino G. miR, “stemness” and skin. Trends Biochem. Sci. 33(12):583-91. pdf

-4. Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A, Lapidot T. CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. J Exp Med. 2008 Sep 29;205(10):2381-95.


-1. Aberdam D, Gambaro K, Aberdam E, Rostagno P, de la Forest Divonne S and Rouleau M. Role of p63 during epidermal commitment of embryonic stem cells. Cell cycle 6:291-4.


-1. Gambaro K, Aberdam E, Virolle T, Aberdam D and Rouleau M. BMP-4 induces the Smad-dependent apoptotic cell death of mouse embryonic stem cell-derived neural progenitors. Cell Death & Diff. 13, 1075-1087.


-1. Thyss R, Virolle-de Thillot V, Imbert V, Peyron JF, Aberdam D and Virolle T. NF-KB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. Embo J. 24:128-137.


-1.Coraux C, Hilmi C, Rouleau M, Spadafora A, Hinnrasky J, Ortonne JP, Dani C, Aberdam D. (2003) Reconstituted skin from murine embryonic stem cells. Curr Biol. 13, 849-53. pdf


-1. Virolle T, Coraux C, Ferrigno O, Cailleteau L, Ortonne JP, Pognonec P, Aberdam D. Binding of USF to a non-canonical E-box following stress results in a cell-specific derepression of the lama3 gene. Nucleic Acids Res. 30, 1789-98.


-1. Ferrigno O., Virolle T., Djabari Z., Ortonne J.P., White R.J., and Aberdam D. Transposable B2 SINE Elements Can Provide a Mobile RNA Polymerase II Promoter. Nature genetics 28, 77-81. pdf


-1.Virolle T., Djabari Z., Ortonne J.P. and Aberdam D. DNA conformation driven by AP-1 triggers cell-specific expression via a strong epithelial enhancer. Embo Reports 1, 328-333.pdf


-1. Virolle T., Monthouel M.N., Djabari Z., Ortonne J.P., Meneguzzi G. and Aberdam D. Three AP-1 binding sites bound by Fra-2/JunD complex cooperate for the regulation of the murine laminin a3A (lama3A) promoter activity by transforming growth factor-beta. J. Biol. Chem. 273, 17318- 17325.


-1. Ferrigno O., Virolle T., Galliano M.F., Chauvin N., Ortonne J.P., Meneguzzi G. and Aberdam D. Murine laminin 5 a3A and a3B isoform chains are generated by usage of two promoters and alternative splicing. J. Biol. Chem. 272, 20502-20508.


-1. Vidal F., Aberdam D., Christiano A.M., Uitto J., Ortonne J.P. and Meneguzzi G. Integrin ß4 mutations are associated with junctional epidermolysis bullosa with pyloric atresia. Nature genetics 10, 229-234.


-1. Aberdam D., Galliano M.F., Vailly J., Pulkkinen L., Bonifas J., Christiano A.M., Tryggvason K., Uitto J., Epstein E.H. Jr, Ortonne J.P. and Menneguzi G. Herlitz's junctional epidermolysis bullosa is genetically linked to mutations in the gene for the g2 subunit of nicein/kalinin (laminin-5). Nature genetics 6, 299-304. pdf


-1. Aberdam D., Negreanu V., Sachs L. and Blatt C. The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts. Mol. Cell. Biol. 11, 554-557. pdf