Production of Cornea from Pluripotent stem cells

We have developped an innovative protocol to produce corneal epithelial cells from induced pluripotent stem cells (cells that have been reprogrammed from patient somatic cells and are growing undefinitely and able to produce any cell type).

This model could be used:

  (1) as an alternative of animals to test drugs and cosmetical products for potential eye toxicity,

  (2) to produce cornea tissue in vitro for transplantation to patients.

Nos travaux ont permis la production de cellules de cornée à partir de cellules souches pluripotentes (cellules obtenues par la reprogrammation de cellules de patients et qui poussent en quantité illimitée et capable ensuite de produire n'importe quel type cellulaire).